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Year Number of Results
1997 1
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2006 1
2009 1
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2014 1
2015 3
2016 1
2017 5
2018 4
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2020 4
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2022 4
2023 2
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35 results

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Page 1
The role of CD47 in pathogenesis and treatment of renal ischemia reperfusion injury.
Isenberg JS, Roberts DD. Isenberg JS, et al. Pediatr Nephrol. 2019 Dec;34(12):2479-2494. doi: 10.1007/s00467-018-4123-z. Epub 2018 Nov 3. Pediatr Nephrol. 2019. PMID: 30392076 Free PMC article. Review.
A number of factors mediate IR injury including the production of reactive oxygen species and inflammatory cell infiltration and activation. In the kidney, IR injury is a major cause of acute injury and secondary loss of renal function. ...Herein, a summary of the maladapt …
A number of factors mediate IR injury including the production of reactive oxygen species and inflammatory cell infiltration and activation. …
Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management.
Rogers NM, Yao M, Novelli EM, Thomson AW, Roberts DD, Isenberg JS. Rogers NM, et al. Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1117-25. doi: 10.1152/ajprenal.00359.2012. Epub 2012 Aug 8. Am J Physiol Renal Physiol. 2012. PMID: 22874763 Free PMC article. Review.
A role of CD47 in renal IRI was recently revealed by the finding that the TSP1-CD47 axis is induced in renal tubular epithelial cells (RTEC) under hypoxia and following IRI. The absence of CD47 in knockout mice increases survival, mitigates RTEC damage, and p …
A role of CD47 in renal IRI was recently revealed by the finding that the TSP1-CD47 axis is induced in renal tubular epithelia …
CD47 limits autophagy to promote acute kidney injury.
El-Rashid M, Ghimire K, Sanganeria B, Lu B, Rogers NM. El-Rashid M, et al. FASEB J. 2019 Nov;33(11):12735-12749. doi: 10.1096/fj.201900120RR. Epub 2019 Aug 31. FASEB J. 2019. PMID: 31480863
These data suggest that activated CD47 promotes AKI through inhibition of autophagy and point to CD47 as a target to preserve renal function following injury.-El-Rashid, M., Ghimire, K., Sanganeria, B., Lu, B., Rogers, N. M. CD47 limits autophagy to promote a …
These data suggest that activated CD47 promotes AKI through inhibition of autophagy and point to CD47 as a target to preserve …
CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps.
Shiratori-Aso S, Nakazawa D, Kudo T, Kanda M, Ueda Y, Watanabe-Kusunoki K, Nishio S, Iwasaki S, Tsuji T, Masuda S, Tomaru U, Ishizu A, Atsumi T. Shiratori-Aso S, et al. JCI Insight. 2023 Aug 8;8(15):e167486. doi: 10.1172/jci.insight.167486. JCI Insight. 2023. PMID: 37368493 Free PMC article.
Immunostaining for CD47 in human renal tissues revealed high CD47 expression in crescentic glomerular lesions of patients with AAV. ...Thus, CD47 blockade would protect against developing glomerulonephritis in AAV via restored efferocytosis of ANCA-induced NE …
Immunostaining for CD47 in human renal tissues revealed high CD47 expression in crescentic glomerular lesions of patients with …
Advances in Anti-metabolic Disease Treatments Targeting CD47.
Gao L, He Z, Wu Y. Gao L, et al. Curr Pharm Des. 2022;28(46):3720-3728. doi: 10.2174/1381612828666221006123144. Curr Pharm Des. 2022. PMID: 36201266 Review.
Subsequently, the role of CD47 has been explored in obesity, fatty liver, and lipotoxic nephropathy, and its utility as a therapeutic target has been investigated using anti-CD47 antibodies or inhibitors of the THBS1/CD47 axis and the CD47/SIRPalpha si …
Subsequently, the role of CD47 has been explored in obesity, fatty liver, and lipotoxic nephropathy, and its utility as a therapeutic …
Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine.
Kale A, Rogers NM, Ghimire K. Kale A, et al. Int J Mol Sci. 2021 Apr 14;22(8):4062. doi: 10.3390/ijms22084062. Int J Mol Sci. 2021. PMID: 33920030 Free PMC article. Review.
Recent advances provide evidence that the cellular signalling pathway comprising the ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range of diseases affecting renal, vascular, and metabolic function, as well as cancer. ...This ha …
Recent advances provide evidence that the cellular signalling pathway comprising the ligand-receptor duo of thrombospondin-1 (TSP1) and C …
Biomarkers in Cardiorenal Syndrome and Potential Insights Into Novel Therapeutics.
Chung EYM, Trinh K, Li J, Hahn SH, Endre ZH, Rogers NM, Alexander SI. Chung EYM, et al. Front Cardiovasc Med. 2022 May 20;9:868658. doi: 10.3389/fcvm.2022.868658. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35669475 Free PMC article. Review.
Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex bi-directional nature of heart and kidney dysfunction is referred to as cardiorenal syndrome, and can be induced by acute or chronic dysfunction of either organ or secondary …
Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex bi-directional nature of heart and ki …
Immune inactivation by CD47 expression predicts clinical outcomes and therapeutic responses in clear cell renal cell carcinoma patients.
Jiang W, Zeng H, Liu Z, Jin K, Hu B, Chang Y, Liu L, Zhu Y, Xu L, Wang Z, Guo J, Xu J. Jiang W, et al. Urol Oncol. 2022 Apr;40(4):166.e15-166.e25. doi: 10.1016/j.urolonc.2021.11.024. Epub 2022 Jan 5. Urol Oncol. 2022. PMID: 34998671
CD8(+) T cells infiltration had discordant prognostic value based on CD47 expression, where high CD8(+) T cell infiltration was associated with worse clinical outcome in CD47(hi) patients and with favorable prognosis in CD47(lo) patients. Patients with mutate …
CD8(+) T cells infiltration had discordant prognostic value based on CD47 expression, where high CD8(+) T cell infiltration was assoc …
Band 3 anion exchanger and its involvement in erythrocyte and kidney disorders.
Tanner MJ. Tanner MJ. Curr Opin Hematol. 2002 Mar;9(2):133-9. doi: 10.1097/00062752-200203000-00009. Curr Opin Hematol. 2002. PMID: 11844997 Review.
Band 3 also binds integral membrane proteins, including the Rh protein complex and CD47. Band 4.2 is important in these associations, which link the Rh complex to the skeleton. ...The article discusses a likely mechanism for dominant distal renal tubular acidosis in which …
Band 3 also binds integral membrane proteins, including the Rh protein complex and CD47. Band 4.2 is important in these associations, …
THBS1/CD47 Modulates the Interaction of gamma-Catenin With E-Cadherin and Participates in Epithelial-Mesenchymal Transformation in Lipid Nephrotoxicity.
Gao L, Yang TT, Zhang JS, Liu HX, Cai DC, Wang LT, Wang J, Li XW, Gao K, Zhang SY, Cao YJ, Ji XX, Yang MM, Han B, Wang S, He L, Nie XY, Liu DM, Meng G, He CY. Gao L, et al. Front Cell Dev Biol. 2021 Feb 18;8:601521. doi: 10.3389/fcell.2020.601521. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33681182 Free PMC article.
Hyperlipidemia, an important risk factor for cardiovascular and end-stage renal diseases, often aggravates renal injury and compromises kidney function. ...These findings indicate that CD47 may serve as a potential therapeutic target in long-term lipid-induce …
Hyperlipidemia, an important risk factor for cardiovascular and end-stage renal diseases, often aggravates renal injury and compromis …
35 results